567565

Sodium Stibogluconate

A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex.

• Synonyme(s) : Sodium Stibogluconate, SSG, Antimony Sodium Gluconate, NaSb^v, PTP Inhibitor XXIV, SHP1 Inhibitor IV
• Formule empirique (notation de Hill): C₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
• Numéro CAS: 16037-91-5
• Poids moléculaire : 907.88
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥90% dry basis (≥30% Sb content, titration)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated; protect from light
• Couleur: white
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/2C6H10O7.3Na.9H2O.3O.2Sb/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h2*2-5,7-8,10H,1H2,(H,12,13);;;;9*1H2;;;;;/q2*-2;3*+1;;;;;;;;;;;;;2*+2/p-2/t2*2-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1
• Clé InChI: CUEDNFKBTFCOSV-UZVLBLASSA-L

Description

Description générale

A pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (EC_max = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (EC_max = 55 µM). Exhibits anti-leishmanial effects.

A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
PTPase activity, including Src homology PTPase-1 (SHP-1)

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: ~11 µM causing 99% inhibition of protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1)

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Heating to 75°C with constant stirring or constant stirring overnight at room temperature may be required for complete solubilization.

Reconstitution

Unstable in solution; reconstitute just prior to use.

Autres remarques

Wortmann, G., et al. 2002. Clin. Infect. Dis.35, 261.
Pathak, M.K. and Yi, T. 2001. J. Immunol.167, 3391.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H332,H411
• Conseils de prudence: P261 - P264 - P271 - P273 - P301 + P312 - P304 + P340 + P312
• Classification des risques: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable