399275
Nω-Hydroxy-nor-L-arginine, Diacetate Salt
A potent, selective, competitive, and high affinity inhibitor of arginase.
Synonyme(s) :
Nω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
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About This Item
Formule empirique (notation de Hill):
C5H12N4O3 · 2C2H4O2
Numéro CAS:
Poids moléculaire :
296.28
Code UNSPSC :
12352209
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
≥97% (TLC)
Forme
solid
Puissance
2 μM IC50
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
desiccated (hygroscopic)
Couleur
off-white
Solubilité
water: 50 mg/mL
Conditions d'expédition
ambient
Température de stockage
−20°C
Description générale
A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.
Actions biochimiques/physiologiques
Primary Target
arginase from rat liver
arginase from rat liver
Secondary Target
mouse macrophages (IC₅₀ = 50 µM)
mouse macrophages (IC₅₀ = 50 µM)
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Autres remarques
Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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