345744

Ganglioside GT_1b, Trisialo, Triammonium Salt, Bovine Brain

Inhibits Con A-stimulated mitogenesis in murine T cells.

• Synonyme(s) : Ganglioside GT_1b, Trisialo, Triammonium Salt, Bovine Brain, Neu5Acα2,3Galβ1,3GalNAcβ1,4(Neu5Acα2,8Neu5Acα2,3)Galβ1,4Glcβ1,1 Ceramide, 3NH₄
• Formule empirique (notation de Hill): C₉₅H₁₆₂N₅O₄₇ · 3NH₄
• Poids moléculaire : 2180.42
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (TLC)
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Solubilité: ethanol: soluble; methanol: soluble
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

Inhibits Con A-stimulated mitogenesis in murine T cells. Lymphocyte marker in cancer patients. Readily converted to GD_1b-disialoganglioside by bacterial and other mammalian neuraminidases without detergent or bile salts.

M.W. 2180.5 (based on stearoyl - 18:0).

Trisialoganglioside prepared from bovine gray matter. Readily converted to GD_1b-disialoganglioside by bacterial and mammalian sialidases without detergent or bile salts. Inhibits mitogenesis in concanavalin A-stimulated murine T-cells. Lymphocyte marker in cancer patients.



Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Inhibits Con A-stimulated mitogenesis in murine T cells

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Irritant (B)

Notes préparatoires

For use in aqueous systems, dissolve in a small amount of ethanol and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions can be filter sterilized.

Reconstitution

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

Autres remarques

Hakomori, S. 1985. Cancer Res.45, 2405.
Momoi, T., et al. 1976. Biochim. Biophys. Acta441, 488.
Warren, L. 1959. J. Biol. Chem.234, 1971.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable