674648

(S)-(−)-2-Methyl-CBS-oxazaborolidine solution

1 M in THF

• Synonyme(s) : α,α-Diphenyl-L-prolinol methylboronic acid cycl-amide ester, (S)-1-Methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2c][1,3,2]oxazaborole, (S)-3,3-Diphenyl-1-methyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole, (S)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole
• Formule empirique (notation de Hill): C₁₈H₂₀BNO
• Numéro CAS: 112022-81-8
• Poids moléculaire : 277.17
• Numéro MDL: MFCD00078439
• Code UNSPSC : 12352005
• ID de substance PubChem : 24885227
• Nomenclature NACRES : NA.22

Propriétés

• Concentration: 1 M in THF
• Indice de réfraction: n20/D 1.460
• Densité: 0.942 g/mL at 25 °C
• Chaîne SMILES: CB1OC([C@@H]2CCCN12)(c3ccccc3)c4ccccc4
• InChI: 1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m0/s1
• Clé InChI: VMKAFJQFKBASMU-KRWDZBQOSA-N

Description

Application

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis

The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C₂-symmetrical ferrocenyl diols, and propargyl alcohols.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08,GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302,H318,H335,H336,H351
• Conseils de prudence: P201 - P210 - P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3
• Organes cibles: Central nervous system, Respiratory system
• Risques supp: EUH018,EUH019
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 5.0 °F - closed cup
• Point d'éclair (°C): -15 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter