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299154

Sigma-Aldrich

L-Methionine-(methyl-13C,d3)

≥99 atom % 13C, ≥99 atom % D, ≥99% (CP)

Synonyme(s) :

SILAC Amino Acid

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About This Item

Formule linéaire :
13CD3SCH2CH2CH(NH2)CO2H
Numéro CAS:
73488-65-0
Poids moléculaire :
153.22
Numéro MDL:
MFCD00002624
Code UNSPSC :
12352209
ID de substance PubChem :
24858018
Nomenclature NACRES :
NA.12

Pureté isotopique

≥99 atom % 13C
≥99 atom % D

Pureté

≥99% (CP)

Forme

powder

Activité optique

[α]25/D +23.1°, c = 1 in 1 M HCl

Technique(s)

protein expression: suitable

Pf

284 °C (dec.) (lit.)

Changement de masse

M+4

Chaîne SMILES 

[2H][13C]([2H])([2H])SCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1+1D3

Clé InChI

FFEARJCKVFRZRR-ZIHWZSJBSA-N

Application

Used in the methodology of stable isotope tagging of epitopes (SITE) for identification of virus-induced peptides in vaccine development.

Conditionnement

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Martin Bachman et al.
Nature chemical biology, 11(8), 555-557 (2015-06-23)
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable
Hugo D Meiring et al.
Molecular & cellular proteomics : MCP, 5(5), 902-913 (2006-01-25)
Identification of peptides presented in major histocompatibility complex (MHC) class I molecules after viral infection is of strategic importance for vaccine development. Until recently, mass spectrometric identification of virus-induced peptides was based on comparative analysis of peptide pools isolated from
Valeria Spadotto et al.
Nucleic acids research, 48(1), 96-115 (2019-11-30)
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Microprocessor and its associated proteins. Through high resolution mass spectrometry (MS)- proteomics we discovered that this complex is extensively methylated, with 84
Daniele Musiani et al.
Science signaling, 12(575) (2019-04-04)
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the involvement of PRMT5, the major type II PRMT, in cell survival and differentiation pathways that are important during development and in tumorigenesis. PRMT5
Daniele Musiani et al.
Cell reports, 30(4), 1208-1222 (2020-01-30)
Protein arginine methyltransferase 1 (PRMT1) is overexpressed in various human cancers and linked to poor response to chemotherapy. Various PRMT1 inhibitors are currently under development; yet, we do not fully understand the mechanisms underpinning PRMT1 involvement in tumorigenesis and chemoresistance.
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