Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

ABSTRACT

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATERIALS

Product Number

Brand

Product Description

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

GF22018553

Platinum, tube, 50mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.1mm, as drawn, 99.95%

GF30259357

Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.95%

GF72819715

Platinum, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%

GF90827185

Platinum, foil, not light tested, 50x50mm, thickness 0.0125mm, as rolled, 99.95%

GF30985050

Platinum, tube, 50mm, outside diameter 6mm, inside diameter 5.6mm, wall thickness 0.2mm, as drawn, 99.95%

GF94628852

Platinum, tube, 500mm, outside diameter 0.5mm, inside diameter 0.42mm, wall thickness 0.04mm, as drawn, 99.95%

GF01692952

Platinum, wire reel, 0.05m, diameter 0.25mm, as drawn, 99.998%

GF78892981

Platinum, wire reel, 0.05m, diameter 0.8mm, annealed, may be used as one component of a thermocouple, 99.99%

GF58198517

Platinum, wire reel, 0.05m, diameter 0.6mm, as drawn, 99.99+%

GF43288487

Platinum, wire reel, 0.05m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%

GF87686173

Platinum, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%

GF55231118

Platinum, wire reel, 0.05m, diameter 1.0mm, as drawn, 99.99+%

GF35428406

Platinum, foil, 15x15mm, thickness 0.2mm, as rolled, 99.95%

GF19578831

Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%

GF04529538

Platinum, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%

GF68611237

Platinum, foil, 0.2m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF55534046

Platinum, foil, 0.05m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%