- HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens.
HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens.
Drug and alcohol dependence (2017-06-18)
G Cristina Brailoiu, Elena Deliu, Jeffrey L Barr, Linda M Console-Bram, Alexandra M Ciuciu, Mary E Abood, Ellen M Unterwald, Eugen Brailoiu
PMID28623807
ABSTRACT
HIV-1 infection and drug abuse are frequently co-morbid and their association greatly increases the severity of HIV-1-induced neuropathology. While nucleus accumbens (NAcc) function is severely perturbed by drugs of abuse, little is known about how HIV-1 infection affects NAcc. We used calcium and voltage imaging to investigate the effect of HIV-1 trans-activator of transcription (Tat) on rat NAcc. Based on previous neuronal studies, we hypothesized that Tat modulates intracellular Ca We provide evidence that Tat triggers a Ca We describe for the first time a HIV-1 Tat-triggered Ca