- "One-pot" syntheses of malondialdehyde adducts of nucleosides.
"One-pot" syntheses of malondialdehyde adducts of nucleosides.
Nucleosides, nucleotides & nucleic acids (2008-01-22)
Jozsef Szekely, Hao Wang, Katherine M Peplowski, Charles G Knutson, Lawrence J Marnett, Carmelo J Rizzo
PMID18205065
ABSTRACT
Short, "one-pot" syntheses of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine are described. These syntheses proceed in improved yield and easier purification than previous syntheses and are well suited for the preparation of isotopically labeled nucleoside adducts for biomarker and metabolic studies.
MATERIALS