Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS

Product Number

Brand

Product Description

266647

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

266671

Sigma-Aldrich

Cobalt, foil, thickness 0.25 mm, ≥99.99% trace metals basis

266701

Sigma-Aldrich

Cobalt, wire, diam. 1.0 mm, 99.995% trace metals basis

356891

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

356867

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

357588

Sigma-Aldrich

Nickel, foil, thickness 0.1 mm, 99.98% trace metals basis

326380

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, ≥99.99%

266981

Sigma-Aldrich

Nickel, powder, <50 μm, 99.7% trace metals basis

577995

Sigma-Aldrich

Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis

357553

Sigma-Aldrich

Nickel, foil, thickness 0.5 mm, 99.98% trace metals basis

267074

Sigma-Aldrich

Nickel, rod, diam. 6.35 mm, ≥99.99% trace metals basis

357626

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.9% trace metals basis

266655

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

203076

Sigma-Aldrich

Cobalt, granular, 99.99% trace metals basis

266639

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

398810

Sigma-Aldrich

Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis

697745

Sigma-Aldrich

Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

GF61615739

Nickel, wire reel, 1m, diameter 1.0mm, as drawn, 99%

767484

Sigma-Aldrich

Nickel, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis

267007

Sigma-Aldrich

Nickel, foil, thickness 0.25 mm, 99.995% trace metals basis

203904

Sigma-Aldrich

Nickel, powder, <150 μm, 99.99% trace metals basis

357634

Sigma-Aldrich

Nickel, wire, diam. 0.25 mm, ≥99.9%

221678

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 2800, slurry, in H₂O, active catalyst

510041

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 4200, slurry, in H₂O, active catalyst

268259

Sigma-Aldrich

Nickel, foil, thickness 0.125 mm, ≥99.9%

267058

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.99% trace metals basis

268283

Sigma-Aldrich

Nickel, powder, <1 μm, 99.8% trace metals basis

510068

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 3202, slurry, in H₂O, active catalyst

510033

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 2400, slurry, in H₂O, active catalyst

GF71400361

Nickel, foam, 300x300mm, thickness 1.6mm, bulk density 0.45g/cm³, porosity 95%, 95%