Skip to Content
Merck

Conjugate addition of lithiated methyl pyridines to enones.

The Journal of organic chemistry (2010-08-14)
Douglass F Taber, Pengfei Guo, Michael T Pirnot
PMID20704446
ABSTRACT

Preparatively useful conjugate addition of lithiated methyl pyridines to cyclic and acyclic enones is reported. Addition of 2-picoline to 3-penten-2-one led to a concise synthesis of the alkaloids (+/-)-senepodine G and (+/-)-cermizine C.

MATERIALS
Product Number
Brand
Product Description
145017
Sigma-Aldrich
3-Penten-2-one, 70%