UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.

UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.

Pharmacogenomics (2012-06-09)

Jia-Ni Tian, Ing-Kang Ho, Hsiao-Hui Tsou, Chiu-Ping Fang, Chin-Fu Hsiao, Chia-Hui Chen, Happy Kuy-Lok Tan, Linen Lin, Chi-Shin Wu, Lien-Wen Su, Chieh-Liang Huang, Yi-Hong Yang, Ming-Lun Liu, Yu-Ting Chen, Shu Chih Liu, Ya-Ting Hsu, Hsiang-Wei Kuo, Chen Ting Liu, Yi-Ting Yang, Andrew Ch Chen, Yu-Huei Shih, Yu-Li Liu

PMID22676193

ABSTRACT

To test whether the genetic polymorphisms within the gene encoding the UGT2B7 gene may have an impact on methadone treatment. Twelve SNPs in UGT2B7 were selected. 366 methadone maintenance treatment patients in Taiwan were recruited and genotyped. In a genotype recessive model, rs6600879, rs6600880, rs4554144, rs11940316, rs7438135, rs7662029, rs7668258, rs7439366, rs4292394 and rs6600893 showed significant associations with severity of withdrawal symptoms (permutation p < 0.002), pupil size (permutation p < 0.048) and tremor (permutation p < 0.008). Haplotypes of GATCAGCCGC and CTCTGATTCT were significantly associated with pupil size score and tremor score (p < 0.034). These results suggest that SNPs of the UGT2B7 gene may play important roles in opiate withdrawal symptoms.

MATERIALS

Product Number

Brand

Product Description

E-006

Supelco

EDDP perchlorate, ampule of 10 mg, certified reference material, Cerilliant^®

E5264

Supelco

2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate, analytical standard, for drug analysis