- Heterocoupling of 2-naphthols enabled by a copper-N-heterocyclic carbene complex.
Heterocoupling of 2-naphthols enabled by a copper-N-heterocyclic carbene complex.
Chemical communications (Cambridge, England) (2013-01-30)
Michael Holtz-Mulholland, Mylène de Léséleuc, Shawn K Collins
PMID23358599
ABSTRACT
The reactivity of a Cu catalyst for oxidative coupling is modulated by a small molecule additive, diethyl malonate, that slows over-oxidation of 2-naphthols. Efficient heterocoupling between electron-rich and electron-poor 2-naphthols/2-naphthylamines affords C(1)-symmetric BINOLs with yields ranging from 35-98%.