- An enantioselective approach to highly substituted tetrahydrocarbazoles through hydrogen bonding-catalyzed cascade reactions.
An enantioselective approach to highly substituted tetrahydrocarbazoles through hydrogen bonding-catalyzed cascade reactions.
Organic letters (2010-02-12)
Xu-Fan Wang, Jia-Rong Chen, Yi-Ju Cao, Hong-Gang Cheng, Wen-Jing Xiao
PMID20146508
ABSTRACT
A hydrogen bonding-mediated double Michael addition-aromatization cascade of 2-propenylindoles and nitroolefins has been disclosed. The methodology allows an efficient synthesis of diverse and structurally complex tetrahydrocarbazoles in good to excellent enantioselectivities and diastereoselectivities.
MATERIALS