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  • An enantioselective approach to highly substituted tetrahydrocarbazoles through hydrogen bonding-catalyzed cascade reactions.

An enantioselective approach to highly substituted tetrahydrocarbazoles through hydrogen bonding-catalyzed cascade reactions.

Organic letters (2010-02-12)
Xu-Fan Wang, Jia-Rong Chen, Yi-Ju Cao, Hong-Gang Cheng, Wen-Jing Xiao
ABSTRACT

A hydrogen bonding-mediated double Michael addition-aromatization cascade of 2-propenylindoles and nitroolefins has been disclosed. The methodology allows an efficient synthesis of diverse and structurally complex tetrahydrocarbazoles in good to excellent enantioselectivities and diastereoselectivities.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,2,3,4-Tetrahydrocarbazole, 99%