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  • Synthesis and activity of 2-oxoamides containing long chain beta-amino acids.

Synthesis and activity of 2-oxoamides containing long chain beta-amino acids.

Journal of peptide science : an official publication of the European Peptide Society (2005-01-07)
Violetta Constantinou-Kokotou, Anna Peristeraki, Christoforos G Kokotos, David A Six, Edward A Dennis
PMID15635664
ABSTRACT

2-Oxoamides based on long chain beta-amino acids were synthesized. 1-Benzyl substituted long chain amines, needed for such synthesis, were synthesized starting from Boc-phenylalaninol. The oxidative conversion of a phenyl group to a carboxyl group was used as the key transformation synthetic step. The compounds synthesized were studied for their activity against GIVA PLA(2), and were proven to be weak inhibitors.

MATERIALS
Product Number
Brand
Product Description
190438
Sigma-Aldrich
(S)-(−)-2-Amino-3-phenyl-1-propanol, 98%, optical purity ee: 99% (HPLC)
284491
Sigma-Aldrich
(R)-(+)-2-Amino-3-phenyl-1-propanol, 98%