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  • Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues.

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues.

Nature communications (2022-07-20)
Qi Song, Ye Yang, Dongxian Jiang, Zhaoyu Qin, Chen Xu, Haixing Wang, Jie Huang, Lingli Chen, Rongkui Luo, Xiaolei Zhang, Yufeng Huang, Lei Xu, Zixiang Yu, Subei Tan, Minying Deng, Ruqun Xue, Jingbo Qie, Kai Li, Yanan Yin, Xuetong Yue, Xiaogang Sun, Jieakesu Su, Fuchu He, Chen Ding, Yingyong Hou
PMID35851595
ABSTRACT

Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 SCCs of 17 organs and 69 ACs of 7 organs. Proteomic comparison between SCCs and ACs identifies distinguishable pivotal pathways and molecules in those pathways play consistent adverse or opposite prognostic roles in ACs and SCCs. A comparison between common and rare SCCs highlights lipid metabolism may reinforce the malignancy of rare SCCs. Proteomic clusters reveal anatomical features, and kinase-transcription factor networks indicate differential SCC characteristics, while immune subtyping reveals diverse tumor microenvironments across and within diagnoses and identified potential druggable targets. Furthermore, tumor-specific proteins provide candidates with differentially diagnostic values. This proteomics architecture represents a public resource for researchers seeking a better understanding of SCCs and ACs.