- Synthesis and biological evaluation of pyridin-2-one nucleosides.
Synthesis and biological evaluation of pyridin-2-one nucleosides.
Nucleosides, nucleotides & nucleic acids (2001-09-21)
C M Huntley, A S Cotterill, J Y Maillard, J Balzarini, C Simons
PMID11563103
ABSTRACT
The synthesis of 1-(beta-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid and the 3-carboxamide as well as a short series of 3N-carboxamides, prepared by TPTU/HOBt coupling of primary amines with 1-(beta-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid, and their evaluation as anti-infective agents is described.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
O-(2-Oxo-1(2H)pyridyl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, ≥99.0% (HPLC)
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