- Ligand-Promoted meta-C-H Functionalization of Benzylamines.
Ligand-Promoted meta-C-H Functionalization of Benzylamines.
Angewandte Chemie (International ed. in English) (2017-04-04)
Peng Wang, Marcus E Farmer, Jin-Quan Yu
PMID28371173
ABSTRACT
Meta-C-H functionalization of benzylamines has been developed using a PdII /transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO2 Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand.
MATERIALS
Product Number
Brand
Product Description