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Key Documents

T7790

Sigma-Aldrich

Tyrphostin 63

≥98%

Synonym(s):

4-Hydroxybenzyl malononitrile

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About This Item

Empirical Formula (Hill Notation):
C10H8N2O
CAS Number:
Molecular Weight:
172.18
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

Assay

≥98%

potency

6500 μM IC50 (negative control)

solubility

DMSO: soluble

storage temp.

2-8°C

SMILES string

Oc1ccc(CC(C#N)C#N)cc1

InChI

1S/C10H8N2O/c11-6-9(7-12)5-8-1-3-10(13)4-2-8/h1-4,9,13H,5H2

InChI key

PDRLQWJJFLVIRC-UHFFFAOYSA-N

Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.

Preparation Note

Tyrphostins are soluble in DMSO. Although the presence of water in the solution may accelerate hydrolysis, frozen solutions in DMSO should still be stable for months.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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