I0274
myo-Inositol Monophosphatase from bovine brain
lyophilized powder, 5-20 units/mg protein
Synonym(s):
myo-Inositol monophosphate phosphohydrolase
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352204
Recommended Products
form
lyophilized powder
specific activity
5-20 units/mg protein
composition
Protein, ~0.5% Bradford
storage temp.
−20°C
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Application
The enzyme plays a critical role in the recycling of inositol to phosphoinositides in the mammalian brain and participates in the phosphatidylinositol signaling pathway. It is inhibited non-competitively by Li+, which may be significant in the treatment of manic depression. The enzyme may help in identifying less toxic substitutes for lithium in manic depressive therapy.
Unit Definition
One unit will form 1.0 μmole of phosphate from inositol 1-phosphate per min at pH 7.4 at 37°C.
Physical form
Lyophilized powder containing HEPES buffer salts, pH 7.5, and stabilizer
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Livia Pasquali et al.
Behavioural pharmacology, 21(5-6), 473-492 (2010-08-12)
This is a short overview focusing on the biochemical interactions underlying the protective effects of lithium at the neuronal level. These include lithium modulation of autophagy, growth factors, excitotoxicity, and a variety of mechanisms underlying cell death, neurogenesis, and neuronal
Sudipta Bhattacharyya et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 67(Pt 4), 471-474 (2011-04-21)
The gene product of the sas2203 ORF of Staphylococcus aureus MSSA476 encodes a 30 kDa molecular-weight protein with a high sequence resemblance (29% identity) to tetrameric inositol monophosphatase from Thermotoga maritima. The protein was cloned, expressed, purified to homogeneity and crystallized.
Toward a crystal-clear view of lithium's site of action.
J M Baraban
Proceedings of the National Academy of Sciences of the United States of America, 91(13), 5738-5739 (1994-06-21)
Zheng Li et al.
Protein science : a publication of the Protein Society, 19(2), 309-318 (2009-12-23)
The inositol monophosphatase (IMPase) enzyme from the hyperthermophilic archaeon Methanocaldococcus jannaschii requires Mg(2+) for activity and binds three to four ions tightly in the absence of ligands: K(D) = 0.8 muM for one ion with a K(D) of 38 muM
Inge De Meyer et al.
British journal of pharmacology, 162(6), 1410-1423 (2010-12-09)
Lithium chloride (LiCl) inhibits inositol monophosphatase (IMPase) at therapeutic concentrations. Given that LiCl induces death in cultured macrophages and that macrophages play an active role in atherosclerotic plaque destabilization, we investigated whether LiCl would induce selective macrophage death to stabilize
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