331856

(2S,3R)-(+)-N-Z-6-oxo-2,3-diphenylmorpholine

99%

• Synonym(s): Benzyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
• Empirical Formula (Hill Notation): C₂₄H₂₁NO₄
• CAS Number: 105228-46-4
• Molecular Weight: 387.43
• MDL number: MFCD00074956
• UNSPSC Code: 12352005
• PubChem Substance ID: 24860003
• NACRES: NA.22

Properties

• Assay: 99%
• optical activity: [α]25/D +66°, c = 5.5 in methylene chloride
• mp: 205-207 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: O=C1CN([C@@H]([C@@H](O1)c2ccccc2)c3ccccc3)C(=O)OCc4ccccc4
• InChI: 1S/C24H21NO4/c26-21-16-25(24(27)28-17-18-10-4-1-5-11-18)22(19-12-6-2-7-13-19)23(29-21)20-14-8-3-9-15-20/h1-15,22-23H,16-17H2/t22-,23+/m1/s1
• InChI key: HECRUWTZAMPQOS-PKTZIBPZSA-N

Description

Application

(2S,3R)-(+)-N-Z-6-oxo-2,3-diphenylmorpholine can be used as a starting material for the synthesis of:

• α-Amino-β-silyloxy-ester, a key intermediate for the preparation of antimalarial drug quinine and its analogs.
• R, R-Formylglycine dimethylacetal, a key intermediate for the preparation of tuberculostatic compound capreomycin IB.
• 2R,5R,6S-2-(Methoxycarbonylmethyl)-5,6-diphenylmorpholine hydrochloride, a key intermediate for the preparation of an antibiotic (+)-negamycin.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves