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Merck

UNC13B

unc-13 homolog B (C. elegans)

Synonyms:
MUNC13, UNC13, Unc13h2
Species:
Human UNC13B (10497), Mouse Unc13b (22249), Rat Unc13b (64830), Horse UNC13B (100055666), domestic guinea pig Unc13b (100726943), naked mole-rat Unc13b (101717680), cow UNC13B (530692), sheep UNC13B (101117731), Domestic Rabbit UNC13B (100345810), domestic cat UNC13B (101089655)
UniProtKB ID:
O14795, Q5VYM8
Gene ID:
  • Human(10497) Summary: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
  • Mouse(22249) unc-13 homolog B (C. elegans)
  • Rat(64830) unc-13 homolog B (C. elegans)
  • Horse(100055666) unc-13 homolog B (C. elegans)
  • domestic guinea pig(100726943) unc-13 homolog B (C. elegans)
  • naked mole-rat(101717680) unc-13 homolog B (C. elegans)
  • cow(530692) unc-13 homolog B (C. elegans)
  • sheep(101117731) unc-13 homolog B (C. elegans)
  • Domestic Rabbit(100345810) unc-13 homolog B (C. elegans)
  • domestic cat(101089655) unc-13 homolog B (C. elegans)
  • dog(100683511) unc-13 homolog B (C. elegans)

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