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TNFRSF11B

tumor necrosis factor receptor superfamily, member 11b

Synonyms:
OCIF, OPG, TR1
Species:
UniProtKB ID:
Gene ID:
  • Human(4982) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
  • Mouse(18383) tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  • Rat(25341) tumor necrosis factor receptor superfamily, member 11b
  • cow(523822) tumor necrosis factor receptor superfamily, member 11b
  • chicken(378803) tumor necrosis factor receptor superfamily, member 11b
  • Zebrafish(407674) tumor necrosis factor receptor superfamily, member 11b
  • dog(482025) tumor necrosis factor receptor superfamily, member 11b
  • Goat(100860896) tumor necrosis factor receptor superfamily, member 11b
  • Domestic Rabbit(100348133) tumor necrosis factor receptor superfamily, member 11b
  • domestic guinea pig(100715850) tumor necrosis factor receptor superfamily, member 11b
  • naked mole-rat(101709512) tumor necrosis factor receptor superfamily, member 11b
  • Horse(100065885) tumor necrosis factor receptor superfamily, member 11b
  • domestic cat(101096878) tumor necrosis factor receptor superfamily, member 11b

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-TNFRSF11B antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-Osteoprotegerin antibody produced in goat, affinity isolated antibody, lyophilized powder,
Species Reactivity
mouse
Application
immunohistochemistry
neutralization

western blot
Anti-Osteoprotegerin antibody produced in goat, affinity isolated antibody,
Species Reactivity
human
Application
western blot

Proteins

Product Number
Description
Species
Osteoprotegerin (OPG) human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Species
human
Osteoprotegerin/Fc Chimera from mouse, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Species
mouse