TEK
TEK tyrosine kinase, endothelial
Synonyms:
CD202B, TIE-2, TIE2, VMCM, VMCM1
Species:
Human TEK (7010), Mouse Tek (21687), Rat Tek (89804), chicken TEK (427368), Zebrafish tek (30747), dog TEK (403714), domestic cat TEK (101091977), cow TEK (280939), domestic guinea pig Tek (100713324), naked mole-rat Tek (101710501)
UniProtKB ID:
Gene ID:
- Human(7010) Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
- Mouse(21687) endothelial-specific receptor tyrosine kinase
- Rat(89804) TEK tyrosine kinase, endothelial
- chicken(427368) TEK tyrosine kinase, endothelial
- Zebrafish(30747) TEK tyrosine kinase, endothelial
- dog(403714) TEK tyrosine kinase, endothelial
- domestic cat(101091977) TEK tyrosine kinase, endothelial
- cow(280939) TEK tyrosine kinase, endothelial
- domestic guinea pig(100713324) TEK tyrosine kinase, endothelial
- naked mole-rat(101710501) TEK tyrosine kinase, endothelial
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-TIE2 (pTyr1108) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-Tie2 Mouse mAb (Ab33), liquid, clone Ab33, Calbiochem®,
Species Reactivity
human, mouse, porcine, rat
Application
Anti-phospho-TIE2 (pTyr992) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-TIE2, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
immunohistochemistry
Small Molecule - Inhibitor
Product Number
Description
Species
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
Species
human