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Merck

TAB1

TGF-beta activated kinase 1/MAP3K7 binding protein 1

Synonyms:
3'-Tab1, MAP3K7IP1
Species:
Human TAB1 (10454), Mouse Tab1 (66513), Rat Tab1 (315139), dog TAB1 (481245), domestic cat TAB1 (101083606), cow TAB1 (519958), sheep TAB1 (101122943), naked mole-rat Tab1 (101696480), domestic guinea pig Tab1 (100735373), Domestic Rabbit TAB1 (100358246) ...More
UniProtKB ID:
Q15750, Q2PP09, Q8IZW2
Gene ID:
  • Human(10454) Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(66513) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • Rat(315139) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • dog(481245) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • domestic cat(101083606) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • cow(519958) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • sheep(101122943) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • naked mole-rat(101696480) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • domestic guinea pig(100735373) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • Domestic Rabbit(100358246) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • Zebrafish(403084) TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • chicken(418014) TGF-beta activated kinase 1/MAP3K7 binding protein 1

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Proteins

Product Number
Description
Species
SRP5088
TAK1-TAB1 (1-303), (437-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human