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Merck

SORT1

sortilin 1

Synonyms:
Gp95, LDLCQ6, NT3
Species:
Human SORT1 (6272), Mouse Sort1 (20661), Rat Sort1 (83576), cow SORT1 (511591), sheep SORT1 (101104538), domestic guinea pig Sort1 (100718269), dog SORT1 (479915), domestic cat SORT1 (101090199), Horse SORT1 (100061385), chicken SORT1 (100858592)
UniProtKB ID:
Q99523, B4DWI3, C0JYZ0, Q8IZ49
Gene ID:
  • Human(6272) Summary: This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq, Jul 2008]
  • Mouse(20661) sortilin 1
  • Rat(83576) sortilin 1
  • cow(511591) sortilin 1
  • sheep(101104538) sortilin 1
  • domestic guinea pig(100718269) sortilin 1
  • dog(479915) sortilin 1
  • domestic cat(101090199) sortilin 1
  • Horse(100061385) sortilin 1
  • chicken(100858592) sortilin 1
  • naked mole-rat(101698000) sortilin 1

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Antibodies

Product Number
Description
Species Reactivity
Application
AMAB91428
Monoclonal Anti-SORT1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL6528, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
S0697
Anti-Sortilin antibody produced in rabbit, lyophilized powder, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot