RTKN
rhotekin
Synonyms:
Species:
Human RTKN (6242), Mouse Rtkn (20166), Rat Rtkn (297383), domestic guinea pig Rtkn (100713192), naked mole-rat Rtkn (101701939), sheep RTKN (101117148), Domestic Rabbit RTKN (100349385), dog RTKN (475788), domestic cat RTKN (101085365), Horse RTKN (100053888)
UniProtKB ID:
Gene ID:
- Human(6242) Summary: This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(20166) rhotekin
- Rat(297383) rhotekin
- domestic guinea pig(100713192) rhotekin
- naked mole-rat(101701939) rhotekin
- sheep(101117148) rhotekin
- Domestic Rabbit(100349385) rhotekin
- dog(475788) rhotekin
- domestic cat(101085365) rhotekin
- Horse(100053888) rhotekin
- cow(539691) rhotekin
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