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Merck

RAP1A

RAP1A, member of RAS oncogene family

Synonyms:
KREV-1, KREV1, RAP1, SMGP21
Species:
Human RAP1A (5906), Mouse Rap1a (109905), Rat Rap1a (295347), domestic cat RAP1A (101094942), sheep RAP1A (101115080), cow RAP1A (282031), chicken RAP1A (419867), Zebrafish rap1a (415242), naked mole-rat Rap1a (101698757), domestic guinea pig Rap1a (100713608)
UniProtKB ID:
P62834, P10113
Gene ID:
  • Human(5906) Summary: The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(109905) RAS-related protein-1a
  • Rat(295347) RAP1A, member of RAS oncogene family
  • domestic cat(101094942) RAP1A, member of RAS oncogene family
  • sheep(101115080) RAP1A, member of RAS oncogene family
  • cow(282031) RAP1A, member of RAS oncogene family
  • chicken(419867) RAP1A, member of RAS oncogene family
  • Zebrafish(415242) RAP1A, member of RAS oncogene family
  • naked mole-rat(101698757) RAP1A, member of RAS oncogene family
  • domestic guinea pig(100713608) RAP1A, member of RAS oncogene family
  • dog(483225) RAP1A, member of RAS oncogene family

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