PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
Synonyms:
CD111, CLPED1, ED4, HIgR, HVEC, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1
Species:
Human PVRL1 (5818), Mouse Pvrl1 (58235), Rat Pvrl1 (192183), dog PVRL1 (489363), domestic cat PVRL1 (101098252), domestic guinea pig Pvrl1 (100724766), naked mole-rat Pvrl1 (101713982), cow PVRL1 (533492), sheep PVRL1 (101116172)
UniProtKB ID:
Gene ID:
- Human(5818) Summary: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
- Mouse(58235) poliovirus receptor-related 1
- Rat(192183) poliovirus receptor-related 1
- dog(489363) poliovirus receptor-related 1 (herpesvirus entry mediator C)
- domestic cat(101098252) poliovirus receptor-related 1 (herpesvirus entry mediator C)
- domestic guinea pig(100724766) poliovirus receptor-related 1 (herpesvirus entry mediator C)
- naked mole-rat(101713982) poliovirus receptor-related 1 (herpesvirus entry mediator C)
- cow(533492) poliovirus receptor-related 1 (herpesvirus entry mediator C)
- sheep(101116172) poliovirus receptor-related 1 (herpesvirus entry mediator C)
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Proteins
Product Number
Description
Species
CD111/Nectin-1/PVRL1 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Species
human