PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms:
P97, RPN1, S2, TRAP2
Species:
Human PSMD2 (5708), Mouse Psmd2 (21762), Rat Psmd2 (287984), dog PSMD2 (478654), domestic cat PSMD2 (101095190), chicken PSMD2 (425294), Zebrafish psmd2 (393518), domestic guinea pig Psmd2 (100725505), naked mole-rat Psmd2 (101711698), sheep PSMD2 (101120791) ...More
UniProtKB ID:
Gene ID:
- Human(5708) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
- Mouse(21762) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- Rat(287984) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- dog(478654) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- domestic cat(101095190) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- chicken(425294) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- Zebrafish(393518) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- domestic guinea pig(100725505) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- naked mole-rat(101711698) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- sheep(101120791) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- cow(539784) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
- Horse(100059081) proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PSMD2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot