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Merck

PARN

poly(A)-specific ribonuclease

Synonyms:
DAN
Species:
Human PARN (5073), Mouse Parn (74108), Rat Parn (360464), domestic guinea pig Parn (100732149), naked mole-rat Parn (101715275), cow PARN (524155), Zebrafish parn (791461), Domestic Rabbit PARN (100351489), domestic cat PARN (101100021), dog PARN (479839) ...More
UniProtKB ID:
O95453, B2RCB3, B4DDG8, B4DWR4, B4E1H6
Gene ID:
  • Human(5073) Summary: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Mouse(74108) poly(A)-specific ribonuclease (deadenylation nuclease)
  • Rat(360464) poly(A)-specific ribonuclease
  • domestic guinea pig(100732149) poly(A)-specific ribonuclease
  • naked mole-rat(101715275) poly(A)-specific ribonuclease
  • cow(524155) poly(A)-specific ribonuclease
  • Zebrafish(791461) poly(A)-specific ribonuclease (deadenylation nuclease)
  • Domestic Rabbit(100351489) poly(A)-specific ribonuclease
  • domestic cat(101100021) poly(A)-specific ribonuclease
  • dog(479839) poly(A)-specific ribonuclease
  • chicken(416423) poly(A)-specific ribonuclease
  • sheep(101112185) poly(A)-specific ribonuclease

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1406220
Anti-PARN antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot