NR1H3
nuclear receptor subfamily 1, group H, member 3
Synonyms:
LXR-a, LXRA, RLD-1
Species:
Human NR1H3 (10062), Mouse Nr1h3 (22259), Rat Nr1h3 (58852), chicken NR1H3 (395221), Zebrafish nr1h3 (548341), naked mole-rat Nr1h3 (101709627), domestic guinea pig Nr1h3 (100725013), Goat NR1H3 (100860906), sheep NR1H3 (101116762), cow NR1H3 (507176) ...More
UniProtKB ID:
Gene ID:
- Human(10062) Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- Mouse(22259) nuclear receptor subfamily 1, group H, member 3
- Rat(58852) nuclear receptor subfamily 1, group H, member 3
- chicken(395221) nuclear receptor subfamily 1, group H, member 3
- Zebrafish(548341) nuclear receptor subfamily 1, group H, member 3
- naked mole-rat(101709627) nuclear receptor subfamily 1, group H, member 3
- domestic guinea pig(100725013) nuclear receptor subfamily 1, group H, member 3
- Goat(100860906) nuclear receptor subfamily 1, group H, member 3
- sheep(101116762) nuclear receptor subfamily 1, group H, member 3
- cow(507176) nuclear receptor subfamily 1, group H, member 3
- domestic cat(101092889) nuclear receptor subfamily 1, group H, member 3
- dog(483625) nuclear receptor subfamily 1, group H, member 3
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Small Molecule - Agonist
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NR1H3 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot
Anti-LXR-A antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-LXR α/LXR β antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-LXRα (N-terminal) antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Small Molecule - Mixed Agonist/Antagonist
Product Number
Description
Species