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Merck

MARCH8

membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase

Synonyms:
MARCH-VIII, MIR, RNF178, c-MIR
Species:
Human MARCH8 (220972), Mouse March8 (71779), Rat March8 (312656), sheep MARCH8 (101120136), naked mole-rat March8 (101701304), Zebrafish march8 (567818), domestic cat MARCH8 (101097021), chicken MARCH8 (423770), Horse MARCH8 (100062110), domestic guinea pig March8 (100718377) ...More
UniProtKB ID:
Q5T0T0, B2R8E7, Q5T0S8, Q8TC72
Gene ID:
  • Human(220972) Summary: MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]
  • Mouse(71779) membrane-associated ring finger (C3HC4) 8
  • Rat(312656) membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
  • sheep(101120136) membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
  • naked mole-rat(101701304) membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
  • Zebrafish(567818) membrane-associated ring finger (C3HC4) 8
  • domestic cat(101097021) membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
  • chicken(423770) membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
  • Horse(100062110) membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
  • domestic guinea pig(100718377) membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
  • dog(606989) membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
  • cow(540667) membrane-associated ring finger (C3HC4) 8

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2101436
Anti-MARCH8 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot