MARCH4
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
Synonyms:
MARCH-IV, RNF174
Species:
Human MARCH4 (57574), Mouse March4 (381270), Rat March4 (367295), sheep MARCH4 (101107500), Zebrafish march4 (562065), Horse MARCH4 (100050538), cow MARCH4 (527624), dog MARCH4 (488515), naked mole-rat March4 (101718651), domestic guinea pig March4 (100725253)
UniProtKB ID:
Gene ID:
- Human(57574) Summary: MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]
- Mouse(381270) membrane-associated ring finger (C3HC4) 4
- Rat(367295) membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
- sheep(101107500) membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
- Zebrafish(562065) membrane-associated ring finger (C3HC4) 4
- Horse(100050538) membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
- cow(527624) membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
- dog(488515) membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
- naked mole-rat(101718651) membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
- domestic guinea pig(100725253) membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
- domestic cat(101082766) membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
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