MAPK8
mitogen-activated protein kinase 8
Synonyms:
JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
Species:
Human MAPK8 (5599), Mouse Mapk8 (26419), Rat Mapk8 (116554), chicken MAPK8 (423778), cow MAPK8 (539941), Goat MAPK8 (100861087), domestic cat MAPK8 (101091310), Horse MAPK8 (100051798), dog MAPK8 (477746), Domestic Rabbit MAPK8 (100346929) ...More
UniProtKB ID:
Gene ID:
- Human(5599) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
- Mouse(26419) mitogen-activated protein kinase 8
- Rat(116554) mitogen-activated protein kinase 8
- chicken(423778) mitogen-activated protein kinase 8
- cow(539941) mitogen-activated protein kinase 8
- Goat(100861087) mitogen-activated protein kinase 8
- domestic cat(101091310) mitogen-activated protein kinase 8
- Horse(100051798) mitogen-activated protein kinase 8
- dog(477746) mitogen-activated protein kinase 8
- Domestic Rabbit(100346929) mitogen-activated protein kinase 8
- sheep(101116201) mitogen-activated protein kinase 8
- domestic guinea pig(100722333) mitogen-activated protein kinase 8
- naked mole-rat(101715259) mitogen-activated protein kinase 8
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-JNK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-phospho-JNK1/2 (pThr183/pTyr185) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, rat
Application
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
PhosphoDetect Anti-SAPK/JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb, liquid, Calbiochem®,
Species Reactivity
caenorhabditis elegans, drosophila, chicken, human, mouse, rat
Application
Monoclonal Anti-MAPK8 antibody produced in mouse, clone 2F11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
proximity ligation assay
western blot
immunofluorescence
proximity ligation assay
western blot
Anti-phospho-JNK (Thr183/Tyr185, Thr221/Tyr223) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
xenopus, bovine, canine, chicken, equine, horse, human, mouse, rat
Application
activity assay
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
JNK1, active, GST tagged from mouse, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse
c-Jun Kinase substrate from rat, >90% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution,
Species
rat