MAN2B1
mannosidase, alpha, class 2B, member 1
Synonyms:
LAMAN, MANB
Species:
Human MAN2B1 (4125), Mouse Man2b1 (17159), Rat Man2b1 (361378), domestic guinea pig Man2b1 (100718205), naked mole-rat Man2b1 (101705792), domestic cat MAN2B1 (493697), cow MAN2B1 (282272), sheep MAN2B1 (101102146), Zebrafish man2b1 (541519), dog MAN2B1 (484932)
UniProtKB ID:
Gene ID:
- Human(4125) Summary: This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
- Mouse(17159) mannosidase 2, alpha B1
- Rat(361378) mannosidase, alpha, class 2B, member 1
- domestic guinea pig(100718205) mannosidase 2, alpha B1
- naked mole-rat(101705792) mannosidase, alpha, class 2B, member 1
- domestic cat(493697) mannosidase, alpha, class 2B, member 1
- cow(282272) mannosidase, alpha, class 2B, member 1
- sheep(101102146) mannosidase, alpha, class 2B, member 1
- Zebrafish(541519) mannosidase, alpha, class 2B, member 1
- dog(484932) mannosidase, alpha, class 2B, member 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MAN2B1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot