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Merck

LIMK1

LIM domain kinase 1

Synonyms:
LIMK, LIMK-1
Species:
Human LIMK1 (3984), Mouse Limk1 (16885), Rat Limk1 (65172), domestic cat LIMK1 (101097861), Domestic Rabbit LIMK1 (100344018), dog LIMK1 (489800), Horse LIMK1 (100062100), naked mole-rat Limk1 (101698555), domestic guinea pig Limk1 (100712921), chicken LIMK1 (373922) ...More
UniProtKB ID:
P53667, B7Z6I8, D3DXF4, D3DXF5, O15283, Q15820, Q15821, Q75MU3
Gene ID:
  • Human(3984) Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
  • Mouse(16885) LIM-domain containing, protein kinase
  • Rat(65172) LIM domain kinase 1
  • domestic cat(101097861) LIM domain kinase 1
  • Domestic Rabbit(100344018) LIM domain kinase 1
  • dog(489800) LIM domain kinase 1
  • Horse(100062100) LIM domain kinase 1
  • naked mole-rat(101698555) LIM domain kinase 1
  • domestic guinea pig(100712921) LIM domain kinase 1
  • chicken(373922) LIM domain kinase 1
  • fruit fly(32207) LIM-kinase1
  • sheep(101110900) LIM domain kinase 1
  • cow(535225) LIM domain kinase 1

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4504460
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
SAB4300103
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
SAB4501755
Anti-LIMK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
L2290
Anti-LIM Kinase 1 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
microarray
western blot