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Merck

ILF3

interleukin enhancer binding factor 3, 90kDa

Synonyms:
CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, TCP110, TCP80
Species:
Human ILF3 (3609), Mouse Ilf3 (16201), Rat Ilf3 (84472), dog ILF3 (484950), sheep ILF3 (101118785), domestic guinea pig Ilf3 (100717410), Horse ILF3 (100057707), domestic cat ILF3 (101096038), naked mole-rat Ilf3 (101723927), cow ILF3 (614936)
UniProtKB ID:
Q12906, A8K6F2, G5E9M5, O43409, Q6P1X1, Q86XY7, Q99544, Q99545
Gene ID:
  • Human(3609) Summary: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
  • Mouse(16201) interleukin enhancer binding factor 3
  • Rat(84472) interleukin enhancer binding factor 3
  • dog(484950) interleukin enhancer binding factor 3, 90kDa
  • sheep(101118785) interleukin enhancer binding factor 3, 90kDa
  • domestic guinea pig(100717410) interleukin enhancer binding factor 3, 90kDa
  • Horse(100057707) interleukin enhancer binding factor 3, 90kDa
  • domestic cat(101096038) interleukin enhancer binding factor 3, 90kDa
  • naked mole-rat(101723927) interleukin enhancer binding factor 3, 90kDa
  • cow(614936) interleukin enhancer binding factor 3, 90kDa

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