IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
Synonyms:
H-IDHB, RP46
Species:
Human IDH3B (3420), Mouse Idh3b (170718), Rat Idh3B (94173), domestic guinea pig Idh3b (100717400), Zebrafish idh3b (415247), dog IDH3B (477177), cow IDH3B (613338), domestic cat IDH3B (101099035), chicken IDH3B (426573), naked mole-rat Idh3b (101709094)
UniProtKB ID:
Gene ID:
- Human(3420) Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
- Mouse(170718) isocitrate dehydrogenase 3 (NAD+) beta
- Rat(94173) isocitrate dehydrogenase 3 (NAD+) beta
- domestic guinea pig(100717400) isocitrate dehydrogenase 3 (NAD+) beta
- Zebrafish(415247) isocitrate dehydrogenase 3 (NAD+) beta
- dog(477177) isocitrate dehydrogenase 3 (NAD+) beta
- cow(613338) isocitrate dehydrogenase 3 (NAD+) beta
- domestic cat(101099035) isocitrate dehydrogenase 3 (NAD+) beta
- chicken(426573) isocitrate dehydrogenase 3 (NAD+) beta
- naked mole-rat(101709094) isocitrate dehydrogenase 3 (NAD+) beta
- sheep(101104080) isocitrate dehydrogenase 3 (NAD+) beta
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