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Merck

GRID2

glutamate receptor, ionotropic, delta 2

Synonyms:
GluD2
Species:
Human GRID2 (2895), Mouse Grid2 (14804), Rat Grid2 (79220), Domestic Rabbit GRID2 (100342468), naked mole-rat Grid2 (101702643), cow GRID2 (536367), dog GRID2 (487863), chicken GRID2 (422520), Zebrafish grid2 (448841), sheep GRID2 (101117078) ...More
UniProtKB ID:
O43424, Q4KKU9, Q4KKV0, Q59FZ1
Gene ID:
  • Human(2895) Summary: Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death. [provided by RefSeq, Jul 2008]
  • Mouse(14804) glutamate receptor, ionotropic, delta 2
  • Rat(79220) glutamate receptor, ionotropic, delta 2
  • Domestic Rabbit(100342468) glutamate receptor, ionotropic, delta 2
  • naked mole-rat(101702643) glutamate receptor, ionotropic, delta 2
  • cow(536367) glutamate receptor, ionotropic, delta 2
  • dog(487863) glutamate receptor, ionotropic, delta 2
  • chicken(422520) glutamate receptor, ionotropic, delta 2
  • Zebrafish(448841) glutamate receptor, ionotropic, delta 2
  • sheep(101117078) glutamate receptor, ionotropic, delta 2
  • domestic cat(101084622) glutamate receptor, ionotropic, delta 2
  • Horse(100053364) glutamate receptor, ionotropic, delta 2
  • domestic guinea pig(100735199) glutamate receptor, ionotropic, delta 2

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