GCLC
glutamate-cysteine ligase, catalytic subunit
Synonyms:
GCL, GCS, GLCL, GLCLC
Species:
Human GCLC (2729), Mouse Gclc (14629), Rat Gclc (25283), fruit fly Gclc (53581), Zebrafish gclc (326857), dog GCLC (609822), domestic guinea pig Gclc (100726181), naked mole-rat Gclc (101718793), Domestic Rabbit GCLC (100342383), cow GCLC (512468) ...More
UniProtKB ID:
Gene ID:
- Human(2729) Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
- Mouse(14629) glutamate-cysteine ligase, catalytic subunit
- Rat(25283) glutamate-cysteine ligase, catalytic subunit
- fruit fly(53581) Glutamate-cysteine ligase catalytic subunit
- Zebrafish(326857) glutamate-cysteine ligase, catalytic subunit
- dog(609822) glutamate-cysteine ligase, catalytic subunit
- domestic guinea pig(100726181) glutamate-cysteine ligase, catalytic subunit
- naked mole-rat(101718793) glutamate-cysteine ligase, catalytic subunit
- Domestic Rabbit(100342383) glutamate-cysteine ligase, catalytic subunit
- cow(512468) glutamate-cysteine ligase, catalytic subunit
- sheep(101114822) glutamate-cysteine ligase, catalytic subunit
- domestic cat(101096568) glutamate-cysteine ligase, catalytic subunit
- Horse(100056731) glutamate-cysteine ligase, catalytic subunit
- chicken(421894) glutamate-cysteine ligase, catalytic subunit
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GCLC antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-GCLC Mouse mAb (3H1), liquid, clone 3H1, Calbiochem®,
Species Reactivity
human
Application
Small Molecule - Inhibitor
Product Number
Description
Species