FURIN
furin (paired basic amino acid cleaving enzyme)
Synonyms:
FUR, PACE, PCSK3, SPC1
Species:
Human FURIN (5045), Mouse Furin (18550), Rat Furin (54281), chicken FURIN (395457), dog FURIN (488746), domestic guinea pig Furin (100733158), domestic cat FURIN (101100308), sheep FURIN (780454), cow FURIN (281374), Horse FURIN (100068931)
UniProtKB ID:
Gene ID:
- Human(5045) Summary: The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(18550) furin (paired basic amino acid cleaving enzyme)
- Rat(54281) furin (paired basic amino acid cleaving enzyme)
- chicken(395457) furin (paired basic amino acid cleaving enzyme)
- dog(488746) furin (paired basic amino acid cleaving enzyme)
- domestic guinea pig(100733158) furin (paired basic amino acid cleaving enzyme)
- domestic cat(101100308) furin (paired basic amino acid cleaving enzyme)
- sheep(780454) furin (paired basic amino acid cleaving enzyme)
- cow(281374) furin (paired basic amino acid cleaving enzyme)
- Horse(100068931) furin (paired basic amino acid cleaving enzyme)
- naked mole-rat(101717888) furin (paired basic amino acid cleaving enzyme)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-FURIN (106-120) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Proteins
Product Number
Description
Species
Furin human, ≥2,000 unit/mL, buffered aqueous solution, recombinant, expressed in baculovirus infected Sf9 cells,
Species
human