FKBP4
FK506 binding protein 4, 59kDa
Synonyms:
FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52
Species:
Human FKBP4 (2288), Mouse Fkbp4 (14228), Rat Fkbp4 (260321), chicken FKBP4 (418261), Domestic Rabbit FKBP4 (100009148), sheep FKBP4 (101114010), cow FKBP4 (508535), domestic cat FKBP4 (101098306), naked mole-rat Fkbp4 (101711168), Zebrafish fkbp4 (321795)
UniProtKB ID:
Gene ID:
- Human(2288) Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
- Mouse(14228) FK506 binding protein 4
- Rat(260321) FK506 binding protein 4
- chicken(418261) FK506 binding protein 4, 59kDa
- Domestic Rabbit(100009148) FK506 binding protein 4, 59kDa
- sheep(101114010) FK506 binding protein 4, 59kDa
- cow(508535) FK506 binding protein 4, 59kDa
- domestic cat(101098306) FK506 binding protein 4, 59kDa
- naked mole-rat(101711168) FK506 binding protein 4, 59kDa
- Zebrafish(321795) FK506 binding protein 4
- dog(477726) FK506 binding protein 4, 59kDa
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