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Merck

FBXO11

F-box protein 11

Synonyms:
FBX11, PRMT9, UBR6, VIT1
Species:
Human FBXO11 (80204), Mouse Fbxo11 (225055), Rat Fbxo11 (301674), domestic cat FBXO11 (101087395), sheep FBXO11 (101107682), naked mole-rat Fbxo11 (101708599), domestic guinea pig Fbxo11 (100729179), chicken FBXO11 (421289), cow FBXO11 (508172), dog FBXO11 (481363)
UniProtKB ID:
Q86XK2, A1L491, Q52ZP1, Q53EP7, Q53RT5, Q8IXG3, Q96E90, Q9H6V8
Gene ID:
  • Human(80204) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
  • Mouse(225055) F-box protein 11
  • Rat(301674) F-box protein 11
  • domestic cat(101087395) F-box protein 11
  • sheep(101107682) F-box protein 11
  • naked mole-rat(101708599) F-box protein 11
  • domestic guinea pig(100729179) F-box protein 11
  • chicken(421289) F-box protein 11
  • cow(508172) F-box protein 11
  • dog(481363) F-box protein 11
  • Horse(100053097) F-box protein 11

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1405285
Monoclonal Anti-FBXO11, (C-terminal) antibody produced in mouse, clone 1A2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot