Skip to Content
Merck

EIF2AK2

eukaryotic translation initiation factor 2-alpha kinase 2

Synonyms:
EIF2AK1, PKR, PRKR
Species:
Human EIF2AK2 (5610), Mouse Eif2ak2 (19106), Rat Eif2ak2 (54287), Zebrafish eif2ak2 (100001092), domestic guinea pig Eif2ak2 (100717384), Domestic Rabbit EIF2AK2 (100009013), domestic cat EIF2AK2 (101082744), sheep EIF2AK2 (101121673), dog EIF2AK2 (611397), naked mole-rat Eif2ak2 (101724844) ...More
UniProtKB ID:
P19525, A8K3P0, D6W584, E9PC80, Q52M43, Q7Z6F6, Q9UIR4
Gene ID:
  • Human(5610) Summary: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Mouse(19106) eukaryotic translation initiation factor 2-alpha kinase 2
  • Rat(54287) eukaryotic translation initiation factor 2-alpha kinase 2
  • Zebrafish(100001092) eukaryotic translation initiation factor 2-alpha kinase 2
  • domestic guinea pig(100717384) eukaryotic translation initiation factor 2-alpha kinase 2
  • Domestic Rabbit(100009013) eukaryotic translation initiation factor 2-alpha kinase 2
  • domestic cat(101082744) eukaryotic translation initiation factor 2-alpha kinase 2
  • sheep(101121673) eukaryotic translation initiation factor 2-alpha kinase 2
  • dog(611397) eukaryotic translation initiation factor 2-alpha kinase 2
  • naked mole-rat(101724844) eukaryotic translation initiation factor 2-alpha kinase 2
  • Horse(100147679) eukaryotic translation initiation factor 2-alpha kinase 2
  • chicken(395147) eukaryotic translation initiation factor 2-alpha kinase 2
  • cow(347700) eukaryotic translation initiation factor 2-alpha kinase 2

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
SAB1404256
Monoclonal Anti-EIF2AK2, (N-terminal) antibody produced in mouse, clone 1D11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB1412653
ANTI-EIF2AK2 antibody produced in mouse, clone 2C2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
WH0005610M1
Monoclonal Anti-EIF2AK2 antibody produced in mouse, clone 1B9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
P0244
Anti-PKR (ET-20) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot
SAB4504639
Anti-phospho-PKR (pThr258) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot