ECH1
enoyl CoA hydratase 1, peroxisomal
Synonyms:
HPXEL
Species:
Human ECH1 (1891), Mouse Ech1 (51798), Rat Ech1 (64526), naked mole-rat Ech1 (101712915), Zebrafish ech1 (450048), sheep ECH1 (101112922), domestic guinea pig Ech1 (100729526), chicken ECH1 (100858352), domestic cat ECH1 (101093730), cow ECH1 (507431)
UniProtKB ID:
Gene ID:
- Human(1891) Summary: This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
- Mouse(51798) enoyl coenzyme A hydratase 1, peroxisomal
- Rat(64526) enoyl CoA hydratase 1, peroxisomal
- naked mole-rat(101712915) enoyl CoA hydratase 1, peroxisomal
- Zebrafish(450048) enoyl CoA hydratase 1, peroxisomal
- sheep(101112922) enoyl CoA hydratase 1, peroxisomal
- domestic guinea pig(100729526) enoyl CoA hydratase 1, peroxisomal
- chicken(100858352) enoyl CoA hydratase 1, peroxisomal
- domestic cat(101093730) enoyl CoA hydratase 1, peroxisomal
- cow(507431) enoyl CoA hydratase 1, peroxisomal
- dog(476467) enoyl CoA hydratase 1, peroxisomal
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