CCL5
chemokine (C-C motif) ligand 5
Synonyms:
D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
Species:
Human CCL5 (6352), Mouse Ccl5 (20304), Rat Ccl5 (81780), sheep CCL5 (101115553), domestic guinea pig Ccl5 (100135495), naked mole-rat Ccl5 (101712384), chicken CCL5 (417465), cow CCL5 (327712), Horse CCL5 (100033925), domestic cat CCL5 (493689)
UniProtKB ID:
Gene ID:
- Human(6352) Summary: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of two N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
- Mouse(20304) chemokine (C-C motif) ligand 5
- Rat(81780) chemokine (C-C motif) ligand 5
- sheep(101115553) chemokine (C-C motif) ligand 5
- domestic guinea pig(100135495) chemokine (C-C motif) ligand 5
- naked mole-rat(101712384) chemokine (C-C motif) ligand 5
- chicken(417465) chemokine (C-C motif) ligand 5
- cow(327712) chemokine (C-C motif) ligand 5
- Horse(100033925) chemokine (C-C motif) ligand 5
- domestic cat(493689) chemokine (C-C motif) ligand 5
- dog(403522) chemokine (C-C motif) ligand 5
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-RANTES antibody produced in goat, affinity isolated antibody, lyophilized powder,
Species Reactivity
human
Application
immunohistochemistry
neutralization
western blot
neutralization
western blot
Monoclonal Anti-RANTES antibody produced in rat, clone 53405.111, purified immunoglobulin, lyophilized powder,
Species Reactivity
mouse
Application
immunocytochemistry
neutralization
neutralization
Anti-CCL5 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human, mouse, rat
Application
western blot