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Merck

CCL21

chemokine (C-C motif) ligand 21

Synonyms:
6Ckine, CKb9, ECL, SCYA21, SLC, TCA4
Species:
Human CCL21 (6366), Rat Ccl21 (298006), dog CCL21 (448796), domestic cat CCL21 (101087275), cow CCL21 (511112), sheep CCL21 (101119957)
UniProtKB ID:
O00585
Gene ID:
  • Human(6366) Summary: This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, May 2013]
  • Rat(298006) chemokine (C-C motif) ligand 21
  • dog(448796) chemokine (C-C motif) ligand 21
  • domestic cat(101087275) chemokine (C-C motif) ligand 21
  • cow(511112) chemokine (C-C motif) ligand 21
  • sheep(101119957) chemokine (C-C motif) ligand 21

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