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Merck

CACNA2D1

calcium channel, voltage-dependent, alpha 2/delta subunit 1

Synonyms:
CACNA2, CACNL2A, CCHL2A
Species:
UniProtKB ID:
Gene ID:
  • Human(781) Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(12293) calcium channel, voltage-dependent, alpha2/delta subunit 1
  • Rat(25399) calcium channel, voltage-dependent, alpha2/delta subunit 1
  • chicken(768444) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • domestic guinea pig(100728887) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • naked mole-rat(101708369) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • cow(282608) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • sheep(101123550) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • dog(610342) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • Domestic Rabbit(100009105) calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • domestic cat(101099450) calcium channel, voltage-dependent, alpha 2/delta subunit 1

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, solid,
Species
human, rat

Small Molecule - Antagonist

Product Number
Description
Species
Felodipine, solid,
Species
human
Nifedipine, ≥98% (HPLC), powder,
Species
rat, mouse, human
Gabapentin, solid,
Species
human, rat
Terodiline hydrochloride, ≥98% (HPLC), solid,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CACNA2D1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-CACNA2D1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Monoclonal Anti-Dihydropyridine Receptor (α2 Subunit) antibody produced in mouse, clone 20A, ascites fluid, buffered aqueous solution,
Species Reactivity
guinea pig, mouse, rabbit, rat
Application
immunohistochemistry
western blot
Anti-Calcium Channel (α2/δSubunit) antibody produced in rabbit, ~1 mg/mL, fractionated antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Calcium Channel (α2/δ-1 Subunit) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
human, mouse, pig, rat
Application
western blot

Small Molecule - Blocker

Product Number
Description
Species
Isradipine, ≥98% (HPLC), solid,
Species
human
Felodipine, solid,
Species
human
Nifedipine, ≥98% (HPLC), powder,
Species
rat, mouse, human
Bepridil hydrochloride, powder,
Species
human
Terodiline hydrochloride, ≥98% (HPLC), solid,
Species
human