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Merck

CA9

carbonic anhydrase IX

Synonyms:
CAIX, MN
Species:
UniProtKB ID:
Gene ID:
  • Human(768) Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008]
  • Zebrafish(566612) carbonic anhydrase IX
  • chicken(770004) carbonic anhydrase IX
  • dog(611933) carbonic anhydrase IX
  • domestic cat(101092802) carbonic anhydrase IX
  • Horse(100055579) carbonic anhydrase IX
  • cow(511923) carbonic anhydrase IX
  • sheep(101115682) carbonic anhydrase IX
  • domestic guinea pig(100729644) carbonic anhydrase IX
  • naked mole-rat(101722784) carbonic anhydrase IX

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CA9 (N-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Monoclonal Anti-CA9 antibody produced in mouse, clone 2D3, ascites fluid,
Species Reactivity
human
Application
ELISA
flow cytometry

immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Methyl 2-(aminosulfonyl)benzoate, 98%,
Species
human
4-Sulfamoylbenzoic acid, 97%,
Species
human
4-Amino-6-chloro-1,3-benzenedisulfonamide, 98%,
Species
human
2-Aminobenzenesulfonamide, 98%,
Species
human, mouse
Sulfanilamide, puriss. p.a., ≥98% (calc. to the dried substance),
Species
human, mouse

Proteins

Product Number
Description
Species
Carbonic Anhydrase 9/CA9 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Species
human