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Merck

BPNT1

3'(2'), 5'-bisphosphate nucleotidase 1

Synonyms:
PIP
Species:
Human BPNT1 (10380), Mouse Bpnt1 (23827), Rat Bpnt1 (64473), chicken BPNT1 (421347), Zebrafish bpnt1 (436627), dog BPNT1 (608525), sheep BPNT1 (101104841), cow BPNT1 (521254), domestic cat BPNT1 (101095075), naked mole-rat Bpnt1 (101709366)
UniProtKB ID:
O95861, A8K7C8, D3DTA9, Q8WVL5, Q9UGJ3
Gene ID:
  • Human(10380) Summary: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
  • Mouse(23827) bisphosphate 3'-nucleotidase 1
  • Rat(64473) 3'(2'), 5'-bisphosphate nucleotidase 1
  • chicken(421347) 3'(2'), 5'-bisphosphate nucleotidase 1
  • Zebrafish(436627) bisphosphate nucleotidase 1
  • dog(608525) 3'(2'), 5'-bisphosphate nucleotidase 1
  • sheep(101104841) 3'(2'), 5'-bisphosphate nucleotidase 1
  • cow(521254) 3'(2'), 5'-bisphosphate nucleotidase 1
  • domestic cat(101095075) 3'(2'), 5'-bisphosphate nucleotidase 1
  • naked mole-rat(101709366) 3'(2'), 5'-bisphosphate nucleotidase 1
  • domestic guinea pig(100736233) 3'(2'), 5'-bisphosphate nucleotidase 1

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